HCID 10516623, 화합물 → 2-Benzylthio-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine

HRID 1031352노트

반응식

HRID 1031352 반응식
[CH2:1]([S:8][C:9]1[N:18]=[C:12]2[N:13]=[C:14](Cl)[CH:15]=[CH:16][N:11]2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:19][O-:20].[Na+]>CO.O>[CH2:1]([S:8][C:9]1[N:18]=[C:12]2[N:13]=[C:14]([O:20][CH3:19])[CH:15]=[CH:16][N:11]2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 10516623HCID 10516623, 화합물HCID 10942334Sodium Methoxide

생성물 1

HCID 107546512-Benzylthio-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine수율 84%

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 962Water용매

실험 절차

A mixture of 6.0 g (22 mmol) of 2-benzylthio-5-chloro-1,2,4-triazolo[1,5-a]pyrimidine in 25 ml of methanol was treated with 5.0 g (23.8 mmol) of a 25% solution of sodium methoxide in methanol. After stirring for 1.5 hours the reaction mixture was diluted with 100 ml of water and neutralized with 3N HCL (aq). The solid which separated was collected by filtration, washed with water and dried to afford 5.0 g (84%) of the desired product as a white solid, m.p. 126°-128° C. IR and 1H NMR spectra were in agreement with the assigned structure.

후처리

  1. customThe solid which separated
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-f423734295f74971b92c627570cc40ce
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04954163

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