HCID 14330456, 화합물 → 5-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

HRID 1031510노트

반응식

HRID 1031510 반응식
C(OC([NH:8][CH:9]1[CH2:14][C:13]2[C:15]([O:19][CH3:20])=[CH:16][CH:17]=[CH:18][C:12]=2[S:11][CH2:10]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[CH3:20][O:19][C:15]1[C:13]2[CH2:14][CH:9]([NH2:8])[CH2:10][S:11][C:12]=2[CH:18]=[CH:17][CH:16]=1

참가 물질

3

반응물 1

HCID 14330456HCID 14330456, 화합물

생성물 1

HCID 143304585-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 10 g of N-t-butoxycarbonyl-3,4-dihydro-5-methoxy-2H-[1]-benzothiopyran-3-amine in 30 ml of trifluoroacetic acid is kept at room temperature for 1 hour. The solvent is removed in vacuo, the residue is treated with 1N NaOH and the product is extracted with ether. After drying over magnesium sulfate, the solvent is removed in vacuo to afford 3,4-dihydro-5-methoxy-2H-[1]-benzothiopyran-3-amine as an oil.

후처리

  1. customThe solvent is removed in vacuo
  2. additionthe residue is treated with 1N NaOH
  3. extractionthe product is extracted with ether
  4. dry with materialAfter drying over magnesium sulfate
  5. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-362d30678378467cb60b2fb47bd9890d
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04954504

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