Ethyl Acetate → 4,4'-Dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime

HRID 1031645노트

반응식

HRID 1031645 반응식
[CH2:1]([O:3][C:4]([CH2:6][C:7](=O)[CH2:8][O:9][N:10]=[C:11]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1)[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)=[O:5])[CH3:2].Cl.[O:30]([NH2:32])[CH3:31].C(OCC)(=O)C>N1C=CC=CC=1>[CH2:1]([O:3][C:4]([CH2:6][C:7](=[N:32][O:30][CH3:31])[CH2:8][O:9][N:10]=[C:11]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1)[C:12]1[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=1)=[O:5])[CH3:2]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 140527694,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-oxopropyl)oxime

생성물 1

HCID 538534414,4'-Dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime수율 96.6%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

3.85 g of the 4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2- oxopropyl)oxime as obtained in Example 1 was dissolved in 5 ml of pyridine and 1 g of methoxylamine hydrochloride was added thereto. Then the obtained mixture was stirred at room temperature. After two hours, the reaction mixture was poured into ethyl acetate, washed with diluted hydrochloric acid and then with a saturated saline solution and purified by silica gel chromatography. Thus 4 g of the title compound was obtained in the form of a colorless oily product.

후처리

  1. washwashed with diluted hydrochloric acid
  2. customwith a saturated saline solution and purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-2cba2dc056924fe7b2b605d33e87a4b6
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04954523

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