Methanol → HCID 178499646, 화합물
반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]([OH:13])=[O:12])=[N:2]1.[CH3:14]O>S(=O)(=O)(O)O>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:2]1참가 물질
4
실험 절차
A solution of 1H-indazole-3-acetic acid (1.0 g) prepared according to J. Am. Chem. Soc., 79, 5245 (1957), in methanol (30 ml) containing five drops of concentrated sulfuric acid was refluxed for 8 hours. The reaction mixture was then concentrated to a low volume and diluted with ethyl acetate (20 ml). The organic layer was washed with water (2×10 ml) and then with sodium bicarbonate solution (10 ml, 10%). The ethyl acetate layer was collected and then dried to obtain the title compound (yield: 0.8g; m.p. 146° C.).
후처리
- temperaturewas refluxed for 8 hours
- concentrationThe reaction mixture was then concentrated to a low volume
- additiondiluted with ethyl acetate (20 ml)
- washThe organic layer was washed with water (2×10 ml)
- customThe ethyl acetate layer was collected
- customdried
출처 및 근거
- ORD 기록
- ord-101dd6dfffea4ab89af305bcc24d10ef
- 출처 데이터셋
- uspto-grants-1990_09
- 특허 번호
- US04954629
반응 노트
불러오는 중…