Nitric Acid → 2-Nitro-4-(trifluoromethoxy)phenol

HRID 1031884

반응식

HRID 1031884 반응식
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[N+:13]([O-])([OH:15])=[O:14]>>[N+:13]([C:6]1[CH:5]=[C:4]([O:3][C:2]([F:11])([F:12])[F:1])[CH:9]=[CH:8][C:7]=1[OH:10])([O-:15])=[O:14]

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 70015p-(Trifluoromethoxy)phenol

생성물 1

HCID 27757752-Nitro-4-(trifluoromethoxy)phenol수율 83%

반응 조건

온도
25 °C

실험 절차

53.4 g (0.3 mol) of 4-trifluoromethoxyphenol were allowed to drop at 25° C. in the course of 30 minutes into 75 ml of 30% strength nitric acid. The mixture was subsequently stirred for 2 hours at 25° C. and then poured into 500 ml of ice water, and the organic phase was separated off. Distillation of the latter yielded 56 g of product having a boiling point of 102° to 103° C. at 26 mbar, which corresponds to a yield of 83% of theory.

후처리

  1. customthe organic phase was separated off
  2. distillationDistillation of the

출처 및 근거

ORD 기록
ord-e8ab67be9728485da81576442d5dcaf0
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04956370

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