Phenethylamine → 2-(3,4-dimethoxyphenyl)-N-(2-phenylethyl)acetamide

HRID 1031902

반응식

HRID 1031902 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12]([OH:14])=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C(N1C=CN=C1)(N1C=CN=C1)=O.[C:27]1([CH2:33][CH2:34][NH2:35])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12]([NH:35][CH2:34][CH2:33][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

참가 물질

5

반응물 3

HCID 1001PhenethylamineHCID 7139(3,4-Dimethoxyphenyl)acetic acidHCID 682631,1'-Carbonyldiimidazole

생성물 1

HCID 2972462-(3,4-dimethoxyphenyl)-N-(2-phenylethyl)acetamide수율 80.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 3,4-dimethoxyphenylacetic acid (17.1 g, 0.090 mol) and carbonyldiimidazole (14.6 g, 0.090 mol) in THF (200 ml) was stirred for 2.5 h in a flask fitted with a drying tube. To this solution was added 2-phenylethylamine (10.9 g, 0.090 mol) in THF (50 ml). After 1 h the THF was evaporated and the residue was treated with water (200 ml) and filtered. The crude amide was washed with water and recrystallized from mixture of 200 ml of methanol and 100 ml of water with a charcoal treatment to afford 21.6 g (80.3%) of the title compound mp 123-124°. A second crop (2.1 g, 7.8%) was obtained after concentrating the mother liquors.

후처리

  1. customfitted with a drying tube
  2. customAfter 1 h the THF was evaporated
  3. additionthe residue was treated with water (200 ml)
  4. filtrationfiltered
  5. washThe crude amide was washed with water
  6. customrecrystallized from mixture of 200 ml of methanol and 100 ml of water with a charcoal treatment

출처 및 근거

ORD 기록
ord-5e52046eb7ea4098a811b1fe15843faa
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04956371

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