Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1'-Carbonyldiimidazole → N-[3-(3,4-Dimethoxyphenyl) propionyl]-2-(3-methylphenyl) ethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 3-(3,4-Dimethoxyphenyl)propionic acid | HCID 75019 | — |
| 반응물 | 2-(3-Methylphenyl)ethan-1-amine | HCID 410085 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-[3-(3,4-Dimethoxyphenyl) propionyl]-2-(3-methylphenyl) ethylamine | HCID 15068909 | 88% |
반응 단계
A solution of 3-(3,4-dimethoxyphenyl) propionic acid (21 g, 0.10 mol) and 16.4 g (0.101 mol) of carbonyldiimidazole in dry THF was stirred for 1 h in a flask protected from moisture. To this solution was added 2-(3-methylphenyl)ethylamine (14.2 g, 0.105 mol) and stirring was continued for 50 min. The solvent was evaporated and the residue was triturated with water and collected by filtration. The crude amide was recrystallized from methanol-water to give 28.6 g (88%) of the title compound mp 100-103°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04956371 |
| 출처 데이터셋 | uspto-grants-1990_09 |
| ORD ID | ord-2f8051cae4bd41a28eeb9872f21c31fe |
| 출처 메모 | uspto-grants-1990_09 |