Methanesulfonyl chloride → N-Ethyl-N-(6-methanesulphonamidoquinol-2-ylmethyl)-4-methanesulphonamidophenethylamine hydrochloride

HRID 1031964노트

반응식

HRID 1031964 반응식
[CH3:1][S:2]([Cl:5])(=[O:4])=[O:3].[CH2:6]([N:8]([CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:25][CH:24]=1)[CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([NH2:20])[CH:16]=2)[N:11]=1)[CH3:7]>N1C=CC=CC=1>[ClH:5].[CH2:6]([N:8]([CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][S:30]([CH3:33])(=[O:31])=[O:32])=[CH:25][CH:24]=1)[CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([NH:20][S:2]([CH3:1])(=[O:4])=[O:3])[CH:16]=2)[N:11]=1)[CH3:7]

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 19813422N-ethyl-N-(6-aminoquinol-2-ylmethyl)-4-methanesulphonamidophenethylamine

생성물 1

HCID 19813440N-Ethyl-N-(6-methanesulphonamidoquinol-2-ylmethyl)-4-methanesulphonamidophenethylamine hydrochloride

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Methanesulphonyl chloride (0.1 g, 1.29 mmole) was reacted with N-ethyl-N-(6-aminoquinol-2-ylmethyl)-4-methanesulphonamidophenethylamine (see Preparation 11B--0.51 g, 1.23 mmole) in pyridine similarly to the procedure of Example 2, giving the free base of the title compound as a gum. The gum was dissolved in ethyl acetate and the solution was diluted with ethereal hydrogen chloride and evaporated to dryness. The residue was triturated with ether to give the title compound as a foam, yield 0.06 g, m.p. 96°.

출처 및 근거

ORD 기록
ord-64de7892265c49a097096e0115a526fd
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04956382

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