Methanol → Anecortave

HRID 1032030

반응식

HRID 1032030 반응식
C([O:4][CH2:5][C:6](=[O:28])[C@:7]1([OH:27])[C@:24]2([CH3:25])[C@H:10]([C@H:11]3[C:21](=[CH:22][CH2:23]2)[C@:19]2([CH3:20])[C:14](=[CH:15][C:16](=[O:26])[CH2:17][CH2:18]2)[CH2:13][CH2:12]3)[CH2:9][CH2:8]1)(=O)C.CO>C(Cl)Cl>[OH:27][C@:7]1([C@:24]2([CH3:25])[C@H:10]([C@H:11]3[C:21](=[CH:22][CH2:23]2)[C@:19]2([CH3:20])[C:14](=[CH:15][C:16](=[O:26])[CH2:17][CH2:18]2)[CH2:13][CH2:12]3)[CH2:9][CH2:8]1)[C:6](=[O:28])[CH2:5][OH:4]

참가 물질

4

반응물 2

HCID 887MethanolHCID 111332Anecortave Acetate

생성물 1

HCID 7074810Anecortave수율 89.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

At room temperature, 1.5 g of 21-acetoxy-17-hydroxy-4,9(11)-pregnadiene-3,20-dione in 40 ml is agitated for 2 hours at room temperature with 15 ml of methanol 0.2N methanolic potassium hydroxide solution. The reaction mixture is introduced into ice water. The precipitated product is suctioned off, dissolved in methylene chloride, washed with water, and dried over sodium sulfate, thus obtaining 1.2 g of 17,21-dihydroxy-4,9(11) pregnadiene3,20-dione; mp 248.2° C.

후처리

  1. washwashed with water
  2. dry with materialdried over sodium sulfate

출처 및 근거

ORD 기록
ord-55c8034840ae47a2b610f62f85552da4
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04956482

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