Ammonium Hydroxide → HCID 15053444, 화합물
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][CH:6]1[CH2:9][N:8]([C:10](Cl)=[O:11])[CH2:7]1.[OH-].[NH4+:17]>O1CCCC1.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][CH:6]1[CH2:9][N:8]([C:10]([NH2:17])=[O:11])[CH2:7]1참가 물질
5
실험 절차
A solution of 5.8 g (0.02 mole) of 3-(3-bromophenoxy)-1-azetidinecarbonyl chloride in 20 ml of tetrahydrofuran was stirred at ambient temperature while 4 ml (0.06 mole) of 57% ammonium hydroxide was slowly added. After stirring for 48 hr, the reaction mixture was diluted with 100 ml of water and the resulting solid collected by filtration (5 g). Recrystallization from isopropanol yielded 3.7 g (59%) of fine beige crystals, m.p. 188°-189° C.
후처리
- additionwas slowly added
- filtrationthe resulting solid collected by filtration (5 g)
- customRecrystallization from isopropanol
출처 및 근거
- ORD 기록
- ord-ef3a345101dd4568946f02d3917ba469
- 출처 데이터셋
- uspto-grants-1990_09
- 특허 번호
- US04956359
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