Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Fumaric Acid → 1-[3-(4-Fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine fumarate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Fumaric Acid | HCID 444972 | — |
| 반응물 | 1-[3-(4-Fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine | HCID 15053405 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 1-[3-(4-Fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine fumarate | HCID 19799593 | 91.3% |
반응 단계
A 2.5 g portion of 1-[3-(4-fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine was dissolved in isopropanol and treated with 0.8 g of fumaric acid dissolved in 2.5 ml of hot isopropanol. Upon cooling, the precipitate was collected by filtration, yielding 3 g (91.3%) of fine white crystals, m.p. 183°-184° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04956359 |
| 출처 데이터셋 | uspto-grants-1990_09 |
| ORD ID | ord-5b7ff3f8c80042018d16a6293997fd92 |
| 출처 메모 | uspto-grants-1990_09 |