Water → HCID 10752540, 화합물

HRID 1032251노트

반응식

HRID 1032251 반응식
O[CH:2]([C:13]1[O:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10].[OH2:18]>P(=O)(O)(O)O.P([O-])([O-])(O)=O.[K+].[K+]>[OH:14][CH:15]1[CH:16]=[CH:17][C:13](=[O:18])[CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10]

참가 물질

4

반응물 2

HCID 962WaterHCID 10728746HCID 10728746, 화합물

생성물 1

HCID 10752540HCID 10752540, 화합물수율 80.7%

시약·촉매·용매 1

HCID 22644153HCID 22644153, 화합물촉매

실험 절차

Into a four necked-flask equipped with a stirrer and a thermometer, 2-(1-hydroxy-7-methoxycarbonylheptyl)-furan 114 g), water (4560 g) and potassium monohydrogen phosphate-phosphoric acid buffer (3.8 g) were charged, and the resulting mixture (pH 4.2) was stirred at 100° C. under nitrogen stream until the starting compound was consumed perfectly. The reaction mixture was cooled and extracted with methylisobutylketone (600 ml) two times. The extracts were combined together and concentrated under reduced pressure to give a mixture (92 g) of 3-hydroxy-2-(6-methoxycarbonylhexyl)-4-cyclopentenone and 4-hydroxy-2-(6-methoxycarbonylhexyl)-2-cyclopentenone. Yield, 80.7%.

후처리

  1. customInto a four necked-flask equipped with a stirrer
  2. customwas consumed perfectly
  3. temperatureThe reaction mixture was cooled
  4. extractionextracted with methylisobutylketone (600 ml) two times
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-96de01cd7656405ca2128f25403a97c5
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04957867

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