Oxalyl chloride → 2,3-Dihydro-6-methoxy-1H-indene-1-carbonyl chloride
반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2[C:12]([OH:14])=O)=[CH:5][CH:4]=1.C(Cl)(=O)C([Cl:18])=O>C(Cl)Cl.CN(C=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2[C:12]([Cl:18])=[O:14])=[CH:5][CH:4]=1참가 물질
5
실험 절차
6-Methoxy-indane-1-carboxylic acid, 6.0 g (31 mmol), a compound of Formula 3, was dissolved in 50 ml of methylene chloride and reacted at ambient temperature with 4.0 ml (46 mmol) of oxalyl chloride in the presence of one drop of DMF. After 2 hours, the reaction mixture was brought to reflux and maintained for 15 minutes. It was then concentrated under vacuum and stirred for about 30 minutes, yielding 6-methoxy-indane-1-carboxylic acid chloride, which was sufficiently pure to be used for the next step.
후처리
- temperatureto reflux
- temperaturemaintained for 15 minutes
- concentrationIt was then concentrated under vacuum
출처 및 근거
- ORD 기록
- ord-1dd86bb3526441e782fc016bbe0fa7f7
- 출처 데이터셋
- uspto-grants-1990_09
- 특허 번호
- US04957914
반응 노트
불러오는 중…