Potassium Iodide → HCID 14556323, 화합물

HRID 1032339노트

반응식

HRID 1032339 반응식
Br[CH:2]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][CH:4]=1.[Br:17][CH2:18][CH2:19][CH2:20][OH:21].C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>O>[F:9][C:6]1[CH:7]=[CH:8][C:3]([CH:2]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[O:21][CH2:20][CH2:19][CH2:18][Br:17])=[CH:4][CH:5]=1

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 123083-Bromo-1-propanolHCID 676651,1'-(Bromomethylene)bis(4-fluorobenzene)

생성물 1

HCID 14556323HCID 14556323, 화합물수율 68.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 36.9 g (0.130 mole) of bromobis(4-fluorophenyl)methane, 21.7 g (0.156 mole) of 3-bromopropanol, 16.6 g (0.156 mole) of sodium carbonate and a few potassium iodide crystals were heated to 130° C. for 16 hours. After cooling, the reaction mixture was diluted with water and extracted with ether. The ethereal phase was washed with water, dried on sodium sulfate and then concentrated to dryness. Distillation of the residue yielded 30.5 g (yield: 68%) of the desired propane.

후처리

  1. temperatureAfter cooling
  2. extractionextracted with ether
  3. washThe ethereal phase was washed with water
  4. customdried on sodium sulfate
  5. concentrationconcentrated to dryness
  6. distillationDistillation of the residue

출처 및 근거

ORD 기록
ord-a0e664139cd24e3b8ea7721e27018984
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04957927

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