Water → 1-Azido-3-acetoxyacetone

HRID 1032358

반응식

HRID 1032358 반응식
Cl[CH2:2][C:3]([CH2:5][O:6][C:7](=[O:9])[CH3:8])=[O:4].O.[N-:11]=[N+:12]=[N-:13].[Na+]>O1CCCC1.CCOCC>[N:11]([CH2:2][C:3]([CH2:5][O:6][C:7](=[O:9])[CH3:8])=[O:4])=[N+:12]=[N-:13]

참가 물질

6

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 384132-Propanone, 1-(acetyloxy)-3-chloro-

생성물 1

HCID 144347801-Azido-3-acetoxyacetone

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

1-Chloro-3-acetoxyacetone (15.05 g.) is dissolved in tetrahydrofuran (50 ml.) and water (25 ml.) is added. Sodium azide (8.7 g.) is added and the mixture is allowed to stir overnight at room temperature. The reaction mixture is diluted with ether (200 ml.) and the aqueous phase is separated. The organic phase is washed once with brine, then dried and evaporated to give 1-azido-3-acetoxyacetone.

후처리

  1. customthe aqueous phase is separated
  2. washThe organic phase is washed once with brine
  3. customdried
  4. customevaporated

출처 및 근거

ORD 기록
ord-961487a4299a4276a608f00d388e8d21
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04957912

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