Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (4-(Benzyloxy)-3-nitrophenyl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 4-(Benzyloxy)-3-nitrobenzaldehyde | HCID 7023554 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (4-(Benzyloxy)-3-nitrophenyl)methanol | HCID 13629301 | 79.8% |
반응 단계
Under ice cooling, 75.7 g of sodium borohydride is introduced within one hour into 128.0 g of 4-benzyloxy-3-nitrobenzaldehyde in 4.2 l of methanol. After 1.5 hours of agitation at room temperature, 1.1 l of 2N HCl is added dropwise. The isolated reaction product is recrystallized from a mixture of 680 ml of diisopropyl ether and 170 ml of isopropanol, thus obtaining 103.0 g of 4-benzyloxy-3-nitrobenzyl alcohol, mp 76°-77° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04958026 |
| 출처 데이터셋 | uspto-grants-1990_09 |
| ORD ID | ord-332bfc4ec5674ccebc0f9df332c27bfd |
| 출처 메모 | uspto-grants-1990_09 |