Thionyl Chloride → 4-Benzyloxy-3-nitrobenzyl chloride

HRID 1032513

반응식

HRID 1032513 반응식
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13]O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][Cl:22])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 13629301(4-(Benzyloxy)-3-nitrophenyl)methanol

생성물 1

HCID 136293024-Benzyloxy-3-nitrobenzyl chloride

실험 절차

Under agitation, 58.3 g of 4-benzyloxy-3-nitrobenzyl alcohol is introduced in incremental portions into 250 ml of thionyl chloride, stirred for 30 minutes at room temperature, and concentrated under vacuum. The residue is recrystallized from diisopropyl ether while decolorizing with active carbon, thus producing 50.9 g of 4-benzyloxy-3-nitrobenzyl chloride, mp 60°-61° C.

후처리

  1. concentrationconcentrated under vacuum
  2. customThe residue is recrystallized from diisopropyl ether

출처 및 근거

ORD 기록
ord-f154fe0b6dc34555ac16b885a6de168a
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04958026

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