N,N-dimethyl-N-[2-(7-nitro-1H-indazol-4-yl)ethenyl]amine → 2-(7-nitro-1H-indazol-4-yl)acetonitrile

HRID 1032526

반응식

HRID 1032526 반응식
C[N:2](C)[CH:3]=[CH:4][C:5]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[C:10]2[C:6]=1[CH:7]=[N:8][NH:9]2>O>[N+:14]([C:11]1[CH:12]=[CH:13][C:5]([CH2:4][C:3]#[N:2])=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2)([O-:16])=[O:15]

참가 물질

3

반응물 1

HCID 54098844N,N-dimethyl-N-[2-(7-nitro-1H-indazol-4-yl)ethenyl]amine

생성물 1

HCID 136293082-(7-nitro-1H-indazol-4-yl)acetonitrile수율 78.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

At room temperature, 23.3 g of N,N-dimethyl-N-[2-(7-nitro-1H-indazol-4-yl)ethenyl]amine and 35.0 g of hydroxylamine-orthosulfonic acid are agitated in 400 ml of water for 24 hours. The precipitate is suctioned off, washed with water, and recrystallized from ethyl acetate, thus obtaining 16.0 g of 2-(7-nitro-1H-indazol-4-yl)acetonitrile, mp 198°-200° C.

후처리

  1. washwashed with water
  2. customrecrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-a29ec0adc9fb4b87a8123b7be4c25b04
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04958026

연결된 노트

불러오는 중…