Potassium Hydroxide → HCID 14856031, 화합물

HRID 1032696노트

반응식

HRID 1032696 반응식
[OH-:1].[K+].[CH2:3]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[N:21]=[C:20]([CH2:22]Cl)[C:19]([C:24]([O:26]CC)=[O:25])=[CH:18][N:17]=2)[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C(O)C>[CH2:3]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[N:21]=[C:20]([CH2:22][OH:1])[C:19]([C:24]([OH:26])=[O:25])=[CH:18][N:17]=2)[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 13769878Ethyl 4-(chloromethyl)-2-[4-(phenylmethyl)-1-piperazinyl]-5-pyrimidinecarboxylate

생성물 1

HCID 14856031HCID 14856031, 화합물수율 44.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethanol (80 ml) and 2.64 g (40.0 mmoles) of 85% potassium hydroxide were added to 5.0 g (13.3 mmoles) of ethyl 2-(4-benzylpiperazino)-4-chloromethylpyrimidine-5-carboxylate (produced in accordance with Referential Example 41 of Japanese Laid-Open Patent Publication No. 140568/1986), and the mixture was refluxed for 30 minutes. Ethanol was evaporated under reduced pressure. The residue was dissolved in water, and adjusted to pH about 4 with concentrated hydrochloric acid. The crystals that formed were collected by filtration, and washed with acetone to give 1.93 g (yield 44%) of 2-(4-benzylpiperazino)-4-hydroxymethylpyrimidine-5-carboxylic acid as crystals.

후처리

  1. customproduced in accordance with Referential Example 41 of Japanese Laid-Open Patent Publication No
  2. temperature140568/1986), and the mixture was refluxed for 30 minutes
  3. customEthanol was evaporated under reduced pressure
  4. dissolutionThe residue was dissolved in water
  5. customThe crystals that formed
  6. filtrationwere collected by filtration
  7. washwashed with acetone

출처 및 근거

ORD 기록
ord-f93eced4a9424a3bbdb3a0f25d70b4d8
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04959368

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