Allyl bromide → HCID 478679, 화합물

HRID 1032721노트

반응식

[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[CH:9][CH:10]=2)[N:5]([CH2:18][CH:19]=[CH2:20])[CH:4]=[C:3]1[C:21](O)=[O:22].O=C1C2C(=CC(C3C=CN=CC=3)=CC=2)[NH:28]C=C1C(OCC)=O.C(Br)C=C>>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[CH:9][CH:10]=2)[N:5]([CH2:18][CH:19]=[CH2:20])[CH:4]=[C:3]1[C:21]([NH2:28])=[O:22]

참가 물질

반응물 3

HCID 7841Allyl bromide

HCID 3016145Ethyl 1,4-dihydro-4-oxo-7-(4-pyridyl)quinoline-3-carboxylate

HCID 10267135HCID 10267135, 화합물

생성물 1

HCID 478679HCID 478679, 화합물

실험 절차

The starting acid, 1,4-dihydro-4-oxo-1-(2-propenyl)-7-(4-pyridinyl)-3-quinolinecarboxylic acid (golden crystals, m.p. 259.5°-261° C. from methanol), was prepared by hydrolysis of the corresponding ethyl ester (yellow powder, m.p. 155°-157° C.), in turn prepared by alkylation of ethyl 1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylate with allyl bromide.

출처 및 근거

ORD 기록: ord-85be1de47ed144d08ea58814dad1209f
출처 데이터셋: uspto-grants-1990_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04959363

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