p-Toluenesulfonic acid → HCID 19937311, 화합물

HRID 1032919노트

반응식

HRID 1032919 반응식
[F:1][C:2]([F:23])([CH2:11][N:12]1[C:16](=[O:17])[C:15]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]2[C:13]1=[O:22])[CH2:3][O:4]C1CCCCO1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)C>[F:23][C:2]([F:1])([CH2:11][N:12]1[C:16](=[O:17])[C:15]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]2[C:13]1=[O:22])[CH2:3][OH:4]

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 19937334HCID 19937334, 화합물

생성물 1

HCID 19937311HCID 19937311, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2,2-difluoro-3-phthalimido-1-tetrahydropyranyloxypropane (2 g, 6.15 mmol), paratoluene sulfonic acid (0.1 g) in absolute ethanol was stirred overnight at room temperature. Then the mixture was concentrated in vacuo, diluted with ethyl acetate and washed with brine. The organic phase was separated, dried over magnesium sulfate and concentrated in vacuo. The crude alcohol 2,2-difluoro-3-phthalimido-1-propanol (1.4 g) was used for the next step without further purification.

후처리

  1. concentrationThen the mixture was concentrated in vacuo
  2. additiondiluted with ethyl acetate
  3. washwashed with brine
  4. customThe organic phase was separated
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe crude alcohol 2,2-difluoro-3-phthalimido-1-propanol (1.4 g) was used for the next step without further purification

출처 및 근거

ORD 기록
ord-7aa0e2122a08404f848052d063812b1d
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05308837

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