2-amino-3,6-dichloroPhenol → 2-Chloromethyl-4,7-dichlorobenzoxazole
반응식
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[OH:10].[ClH:11].ClN=CC(O[CH2:18][CH3:19])=O>C(Cl)Cl>[Cl:11][CH2:18][C:19]1[O:10][C:3]2[C:4]([Cl:9])=[CH:5][CH:6]=[C:7]([Cl:8])[C:2]=2[N:1]=1참가 물질
4
실험 절차
To a solution of 2-amino-3,6-dichlorophenol (23.91 g, 134 mmol) in methylene chloride (270 mL), solid ethyl chloroiminoacetate hydrogen chloride (31.9 g, 202 mmol) was added. The resultant slurry was stirred at room temperature overnight, then filtered through a plug of Celite, and concentrated under reduced pressure (15 torr). The solid residue was subjected to column chromatography on silica gel (elution with chloroform). Collection and concentration of appropriate fractions yielded 26.6 g (86%) of 2-chloromethyl-4,7-dichlorobenzoxazole.
후처리
- filtrationfiltered through a plug of Celite
- concentrationconcentrated under reduced pressure (15 torr)
- customCollection and concentration of appropriate fractions
출처 및 근거
- ORD 기록
- ord-68abe93ea1c244cd96fc91713bec7e3d
- 출처 데이터셋
- uspto-grants-1994_05
- 특허 번호
- US05308854
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