Dimethylformamide → 2-Hydroxy-6-octyloxycarbonylnaphthalene

HRID 1033146

반응식

HRID 1033146 반응식
F[C:2](F)(F)[CH:3]([OH:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].CN(C)[CH:15]=[O:16].[CH2:18](N(CC)CC)[CH3:19].[C:25]1([C:34]2[CH:39]=[CH:38][C:37]([C:40](Cl)=[O:41])=CC=2)[CH:30]=[CH:29]C(C(Cl)=O)=CC=1>C(Cl)Cl>[OH:10][C:3]1[CH:4]=[CH:5][C:6]2[C:18](=[CH:19][CH:9]=[C:8]([C:15]([O:41][CH2:40][CH2:37][CH2:38][CH2:39][CH2:34][CH2:25][CH2:30][CH3:29])=[O:16])[CH:7]=2)[CH:2]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 75374[1,1'-Biphenyl]-4,4'-dicarbonyl dichlorideHCID 978042-Octanol, 1,1,1-trifluoro-

생성물 1

HCID 542866972-Hydroxy-6-octyloxycarbonylnaphthalene수율 105.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Optically active 1,1,1-trifluoro-2-octanol (0.5 g), dimethylformamide (0.35 g) and triethylamine (0.64 g) were dissolved in 20 ml of methylene chloride. To this solution was added in small portions a solution of 4,4'-biphenyldicarboxylic acid dichloride (1.6 g) obtained in 2) of Example 7 in 50 ml of methylene chloride under ice-cooling, and the mixture was stirred for about 20 hours. Next, 2-hydroxy-6-octyloxycarbonylnaphthalene (0.86 g) obtained in 1) was dissolved in 30 ml of methylene chloride and added in small portions to the reaction mixture. The resulting mixture was stirred for about 20 hours.

후처리

  1. temperaturecooling

출처 및 근거

ORD 기록
ord-637059eaa21948d0bda6664d9a4400bd
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05310500

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