Methyl Thioglycolate → 2-Chloro-4-fluoro-5-nitrothiobenzoic acid (methoxycarbonylmethyl) ester

HRID 1033214노트

반응식

HRID 1033214 반응식
ClC1C(C([CH2:10][C:11]([O:13][CH3:14])=[O:12])=S)=CC(N=C2N3N(CCCC3)C(=O)S2)=C(F)C=1.[Cl:27][C:28]1[CH:36]=[C:35]([F:37])[C:34]([N+:38]([O-:40])=[O:39])=[CH:33][C:29]=1[C:30](Cl)=[O:31].COC(=O)C[SH:45]>C(OCC)(=O)C>[CH3:14][O:13][C:11]([CH2:10][O:31][C:30](=[S:45])[C:29]1[CH:33]=[C:34]([N+:38]([O-:40])=[O:39])[C:35]([F:37])=[CH:36][C:28]=1[Cl:27])=[O:12]

참가 물질

5

반응물 3

HCID 16907Methyl ThioglycolateHCID 151243842-Chloro-4-fluoro-5-nitrobenzoyl chlorideHCID 542425799-[4-Chloro-2-fluoro-5-(methoxycarbonylmethylthiocarbonyl)-phenylimino]-8-thia-1,6-diazabicyclo[4.3.0]nonan-7-one

생성물 1

HCID 540569242-Chloro-4-fluoro-5-nitrothiobenzoic acid (methoxycarbonylmethyl) ester

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The preparation of 9-[4-chloro-2-fluoro-5-(methoxycarbonylmethylthiocarbonyl)-phenylimino]-8-thia-1,6-diazabicyclo[4.3.0]nonan-7-one is given by way of example: ##STR22## 48 g of 2-chloro-4-fluoro-5-nitrobenzoic acid chloride are added dropwise, with stirring, at room temperature to a solution of 20 ml of thioglycolic acid methyl ester in 100 ml of ethyl acetate. The batch is stirred for 18 hours and then the solvent is evaporated off in vacuo to yield 19 g of 2-chloro-4-fluoro-5-nitrothiobenzoic acid (methoxycarbonylmethyl) ester in the form of an oil having nD23 : 1.5709.

후처리

  1. customthe solvent is evaporated off in vacuo

출처 및 근거

ORD 기록
ord-1d7d8caf462e4bab92a4806ab67409e8
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05310722

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