HCID 86747828, 화합물 → (cis) 3,3,5-Trimethylcyclohexyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropionate

HRID 1033231노트

반응식

HRID 1033231 반응식
[Cl:1][C:2]1[CH:34]=[CH:33][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:32]=[CH:31][C:14]([O:15][C:16]([CH3:30])([CH3:29])[C:17]([O:19][C@H:20]3[CH2:25][C@H:24]([CH3:26])[CH2:23][C:22]([CH3:28])([CH3:27])[CH2:21]3)=[O:18])=[CH:13][CH:12]=2)=[O:7])=[CH:4][CH:3]=1>[K+].[Br-]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:32]=[CH:31][C:14]([O:15][C:16]([CH3:29])([CH3:30])[C:17]([O:19][C@H:20]3[CH2:25][C@@H:24]([CH3:26])[CH2:23][C:22]([CH3:27])([CH3:28])[CH2:21]3)=[O:18])=[CH:13][CH:12]=2)=[O:7])=[CH:33][CH:34]=1

참가 물질

3

반응물 1

HCID 86747828HCID 86747828, 화합물

생성물 1

HCID 86747829(cis) 3,3,5-Trimethylcyclohexyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropionate

시약·촉매·용매 1

HCID 253877Potassium Bromide용매

실험 절차

The reaction is carried out under the same conditions as in Example 3 and with the same proportions of reactants. After chromatography on a silica column, the product can be recrystallized from ethyl acetate to give the title derivative in the form of white crystals melting at 122° C. (capillary). Thin layer chromatography under the conditions already described shows a single spot whose Rf of 0.2 is identical to that of the product of Example 3. The IR spectrum run in KBr has the same principal characteristic bands as in Example 3, although the fine bands between 1000 and 600 cm-1 are markedly different.

출처 및 근거

ORD 기록
ord-ddeb70bed69946b6aa1b9548c4483e62
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05310757

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