4-Hydroxybenzoic Acid → Ethylene glycol MONO-4-hydroxybenzoate

HRID 1033284노트

반응식

HRID 1033284 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH2:11]1[O:13][CH2:12]1>C(O)(C)C>[OH:13][CH2:12][CH2:11][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[CH:3][CH:4]=1

참가 물질

4

반응물 2

HCID 1354-Hydroxybenzoic AcidHCID 6354Ethylene Oxide

생성물 1

HCID 267950Ethylene glycol MONO-4-hydroxybenzoate

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Into an autoclave, 138 parts by weight of p-hydroxybenzoic acid, 1 part by weight of Na2CO2 and 300 parts by weight of isopropanol were charged, and at 90° C., 66 parts by weight of ethylene oxide was added thereto, and the reaction was conducted. After the reaction, the mixture was cooled, and the precipitate was collected by filtration and recrystallized twice from water to obtain 55 parts by weight of p-hydroxylbenzoic acid-β-hydroxyethyl ester ##STR88## having a melting point of 141° C. The structure was confirmed by 1H-NMR.

후처리

  1. customAfter the reaction
  2. temperaturethe mixture was cooled
  3. filtrationthe precipitate was collected by filtration
  4. customrecrystallized twice from water

출처 및 근거

ORD 기록
ord-06662c88b742439d822a83102e60ca05
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05310859

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