Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (2R*,4S*)-2-benzyl-1-(3,5-bis(trifluoromethyl)benzoyl)-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3,5-Bis(trifluoromethyl)benzoic acid | HCID 12889 | — |
| 반응물 | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| 반응물 | (2R*,4S*)-2-Benzyl-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine | HCID 22863105 | — |
| 생성물 | (2R*,4S*)-2-benzyl-1-(3,5-bis(trifluoromethyl)benzoyl)-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine | HCID 57308278 | 79% |
반응 단계
150 mg (0.384 mmol) of (2R*,4S*)-2-benzyl-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine are reacted in analogy to Example 4a with 93 mg (0.461 mmol) of 3,5-bis(trifluoromethyl)benzoic acid, 117 mg (0.461 mmol) of bis(2-oxo-3-oxazolidinyl)phosphinic chloride and 118 μl (0.845 mmol) of triethylamine. The title compound (191 mg, 79%) is obtained as oil. TLC: methylene chloride/methanol/conc. ammonia (2000:50:1) Rf =0.79, FD-MS: M+ =630.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05310743 |
| 출처 데이터셋 | uspto-grants-1994_05 |
| ORD ID | ord-3d0da9e2eca94c6aafafc7bf2dd00cad |
| 출처 메모 | uspto-grants-1994_05 |