Benzyl Bromide → 7,8-Dihydro-2-(phenylmethoxy)-5(6H)-quinolinone

HRID 1033503노트

반응식

HRID 1033503 반응식
[O:1]=[C:2]1[CH2:11][CH2:10][CH2:9][C:8]2[NH:7][C:6](=[O:12])[CH:5]=[CH:4][C:3]1=2.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(=O)([O-])[O-].[Ag+2].C1(C)C=CC=CC=1>[O:1]=[C:2]1[CH2:11][CH2:10][CH2:9][C:8]2[N:7]=[C:6]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:5]=[CH:4][C:3]1=2

참가 물질

5

반응물 2

HCID 7498Benzyl BromideHCID 2674502-Hydroxy-7,8-dihydro-5(6H)-quinolinone

생성물 1

HCID 104449777,8-Dihydro-2-(phenylmethoxy)-5(6H)-quinolinone수율 89%

시약·촉매·용매 2

HCID 178418647HCID 178418647, 화합물촉매HCID 1140Toluene용매

실험 절차

A suspension of 5,6,7,8-tetrahydro-5-oxo-2(1H)-quinolinone (33.0 g), silver carbonate (35.0 g), benzyl bromide (44.4 g), and toluene (400 ml) was stirred at room temperature for 72 hrs. The mixture was filtered and the filtrate was concentrated. Trituration of the residue with petroleum ether gave 45.6 g (83%) of product.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-9a4cb8125e774473a9f8691548d992e6
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05310914

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