HCID 15341804, 화합물 → HCID 15341825, 화합물

HRID 1033645노트

반응식

HRID 1033645 반응식
[OH:1][C:2]1[C:14]([CH2:15][CH:16]=[CH2:17])=[C:13]([OH:18])[CH:12]=[CH:11][C:3]=1[C:4]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5]>C(O)C.[Pd]>[OH:1][C:2]1[C:14]([CH2:15][CH2:16][CH3:17])=[C:13]([OH:18])[CH:12]=[CH:11][C:3]=1[C:4]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5]

참가 물질

4

반응물 1

HCID 15341804HCID 15341804, 화합물

생성물 1

HCID 15341825HCID 15341825, 화합물수율 86%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

1-[2,4-dihydroxy-3-(2-propenyl)benzoyl]pyrrolidine (750 mg) in 2 ml ethanol was hydrogenated at room temperature and 5 psi for three hours using 4% Pd/C as catalyst. The solvent was removed under vacuum and the residue was chromatographed on silica gel using 50/50 ethyl acetate/hexane as eluant to give the product (650 mg).

후처리

  1. customwas hydrogenated at room temperature
  2. customThe solvent was removed under vacuum
  3. customthe residue was chromatographed on silica gel using 50/50 ethyl acetate/hexane as eluant

출처 및 근거

ORD 기록
ord-ca9468b92a374f6a99fc3bb346ab8b1a
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05310951

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