1-(2-Pyrimidinyl)piperazine → HCID 19024283, 화합물

HRID 1033714노트

반응식

HRID 1033714 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12](=[O:13])[C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[NH:9][CH2:8][C:7]1=[O:18].[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>O1CCOCC1>[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:12](=[O:13])[C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[NH:9][CH2:8][C:7]2=[O:18])[CH2:27][CH2:26]1

참가 물질

4

반응물 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 19024285HCID 19024285, 화합물

생성물 1

HCID 19024283HCID 19024283, 화합물수율 87%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of 70 mg of the compound of Example 14 dissolved in 10 ml of dioxane was added 111 mg (3 equivalents) of 1-(2-pyrimidinyl)piperazine, and the mixture heated under reflux for 8 hours. The reaction treatment and purification were conducted in the same manner as in Example 17 to obtain 77.0 mg of the desired compound (yield 87%). The maleate was obtained by converting the product to maleate, followed by recrystallization from methylene chloride-ether.

후처리

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 8 hours
  3. customThe reaction treatment and purification

출처 및 근거

ORD 기록
ord-3601596f97aa4a47988737b2d801c273
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05312625

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