2-(N-Ethoxycarbonyl-N-propargylaminomethyl)-pyrimidine → ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

HRID 1033745노트

반응식

HRID 1033745 반응식
[CH2:1]([O:3][C:4]([N:6]([CH2:10][C:11]1[N:16]=[CH:15][CH:14]=[CH:13]N=1)[CH2:7][C:8]#C)=[O:5])[CH3:2]>C1(C)C(C)=CC=CC=1>[N:16]1[CH:15]=[CH:14][CH:13]=[C:8]2[CH2:7][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:10][C:11]=12

참가 물질

3

반응물 1

HCID 189536422-(N-Ethoxycarbonyl-N-propargylaminomethyl)-pyrimidine

생성물 1

HCID 18953634ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

7.7 g (35 mmol) of 2-(N-ethoxycarbonyl-N-propargylaminomethyl)-pyrimidine are refluxed for 40 hours in 150 ml of xylene. The mixture is concentrated, and the residue is recrystallised from ligroin.

후처리

  1. concentrationThe mixture is concentrated
  2. customthe residue is recrystallised from ligroin

출처 및 근거

ORD 기록
ord-9befbd0e928f41b4a752bf004b0bbba9
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05312823

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