Acetone → {[(2-Methyl-1-nitropropan-2-yl)sulfanyl]methyl}benzene

HRID 1033822노트

반응식

HRID 1033822 반응식
[CH3:1][C:2]([CH3:4])=O.[CH2:5]([SH:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[N+:13]([CH3:16])([O-:15])=[O:14].N1CCCCC1>C1C=CC=CC=1.O>[CH2:5]([S:12][C:2]([CH3:4])([CH3:1])[CH2:16][N+:13]([O-:15])=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

7

반응물 4

HCID 180AcetoneHCID 6375NitromethaneHCID 7509Benzyl mercaptanHCID 8082Piperidine

생성물 1

HCID 14613816{[(2-Methyl-1-nitropropan-2-yl)sulfanyl]methyl}benzene

시약·촉매·용매 2

HCID 241Benzene용매HCID 962Water용매

실험 절차

Acetone (25 g), benzyl mercaptan (53 g), nitromethane (26.2 g), and piperidine (8 cm3) were dissolved in benzene (150 cm3) and the mixture heated under reflux with azeotropic removal of water. After 48 h the reaction mixture was allowed to cool and washed first with dilute hydrochloric acid, then with water. The remaining solution was dried (MgSO4) and the solvent then removed under reduced pressure to give the nitro system (76.5 g, 85%). This material was sufficiently pure to be used without further purification.

후처리

  1. temperaturethe mixture heated
  2. temperatureto cool
  3. washwashed first with dilute hydrochloric acid
  4. dry with materialThe remaining solution was dried (MgSO4)
  5. customthe solvent then removed under reduced pressure

출처 및 근거

ORD 기록
ord-f1507ad9f5b4440ba0987a3e0f60a33b
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05312904

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