Potassium Hydroxide → HCID 9971689, 화합물

HRID 1034337

반응식

HRID 1034337 반응식
[CH2:1]([N:3]([CH2:26][CH3:27])[S:4]([C:7]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:10]2[N:11]=C(C3C=CC=CC=3)[O:13][C:9]=2[CH:8]=1)(=[O:6])=[O:5])[CH3:2].[OH-].[K+]>C(O)C>[CH2:26]([N:3]([CH2:1][CH3:2])[S:4]([C:7]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:10]([NH2:11])=[C:9]([OH:13])[CH:8]=1)(=[O:6])=[O:5])[CH3:27]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 3715238N,N-Diethyl-2-phenylnaphtho[1,2-d][1,3]oxazole-5-sulfonamide

생성물 1

HCID 9971689HCID 9971689, 화합물수율 154.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of N,N-diethyl-2-phenylnaphth[1,2-d]oxazole-5-sulfonamide (38.1 g, 100 mmol), 20% KOH (140 ml) and ethanol (180 ml) was refluxed for 24 h under nitrogen and the product was extracted with ethyl acetate (3×500 ml). The combined extracts were dried over anhydrous sodium sulfate and the solvent evaporated to give 45.4 g crude N,N-diethyl-4-amino-3-hydroxy-1-naphthalenesulfonamide as a black sticky oil (50% pure by NMR). An analytical sample was prepared by column chromatography (chloroform) to give pure N,N-diethyl-4-amino-3-hydroxy-1-naphthalenesulfonamide as a glassy material which upon trituration with ether gave a black solid, m.p. 120°-122° C.

후처리

  1. temperaturewas refluxed for 24 h under nitrogen
  2. extractionthe product was extracted with ethyl acetate (3×500 ml)
  3. dry with materialThe combined extracts were dried over anhydrous sodium sulfate
  4. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-029b2ddab4604ea28c30360825584374
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05314998

연결된 노트

불러오는 중…