Thionyl Chloride → 10-Methylacridan-9-carboxylic acid chloride

HRID 1034584노트

반응식

HRID 1034584 반응식
[CH3:1][N:2]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]([C:16]([OH:18])=O)[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.S(Cl)([Cl:21])=O.C1C(N=NC2C=CC(N)=C(S([O-])(=O)=O)C=2)=CC=C(S([O-])(=O)=O)C=1.[Na+].[Na+]>ClCCl>[CH3:1][N:2]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]([C:16]([Cl:21])=[O:18])[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 75918Benzenesulfonic acid, 2-amino-5-(2-(4-sulfophenyl)diazenyl)-, sodium salt (1:?)HCID 1039934110-Methylacridan-9-carboxylic acid

생성물 1

HCID 5452072910-Methylacridan-9-carboxylic acid chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Into a 50 mL round bottom flask equipped with magnetic stirrer and under an argon atmosphere was charged a solution of 0.305 parts of 10-methylacridan-9-carboxylic acid (77) in 15 mL of dichloromethane and cooled to 5° C. (ice-water). Then, 1.05 parts of thionyl chloride was added to the cold yellow acid solution and stirred for 1.5 hr at a temperature below 15° C. The light red brown solution was concentrated under reduced pressure and the residue was dried for 15 min to give acid chloride (78).

후처리

  1. customInto a 50 mL round bottom flask equipped with magnetic stirrer and under an argon atmosphere
  2. concentrationThe light red brown solution was concentrated under reduced pressure
  3. customthe residue was dried for 15 min

출처 및 근거

ORD 기록
ord-7aa3577afe0645c797e04fc91e72a4c2
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546150B2

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