Thionyl Chloride → 3-tert-Butyldimethylsilyloxybenzoyl chloride

HRID 1034589노트

반응식

HRID 1034589 반응식
[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12](O)=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].S(Cl)([Cl:20])=O>>[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([Cl:20])=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 183695873-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid

생성물 1

HCID 124484873-tert-Butyldimethylsilyloxybenzoyl chloride

실험 절차

Into a 100 mL round bottom flask a mixture of 5 parts of 3-tert-butyldimethylsilyloxybenzoic acid and 25 mL of thionyl chloride was heated at reflux for 90 mins. The reaction mixture was concentrated under reduced pressure to give an oil, yield 5.77 parts of the following structure.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 90 mins
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customto give an oil
  5. customyield 5.77 parts of the following structure

출처 및 근거

ORD 기록
ord-83a2bddd1edd472f94e794c5a6a34303
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546150B2

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