3-tert-Butyl-5-isocyanato-1-phenyl-1H-pyrazole → 1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-methyl-2-oxo-1,2-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

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[C:1]([C:5]1[CH:9]=[C:8]([N:10]=[C:11]=[O:12])[N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:19][C:20]1[CH:38]=[CH:37][C:23]([O:24][C:25]2[C:34]3[NH:33][C:32](=[O:35])[C:31]([CH3:36])=[N:30][C:29]=3[N:28]=[CH:27][CH:26]=2)=[CH:22][C:21]=1[F:39]>>[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:19][C:20]2[CH:38]=[CH:37][C:23]([O:24][C:25]3[C:34]4[NH:33][C:32](=[O:35])[C:31]([CH3:36])=[N:30][C:29]=4[N:28]=[CH:27][CH:26]=3)=[CH:22][C:21]=2[F:39])=[O:12])[N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:6]=1)([CH3:4])([CH3:2])[CH3:3]