Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Naphthol, 1,6-dibromo-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 6-Bromo-2-naphthalenol | HCID 27144 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2-Naphthol, 1,6-dibromo- | HCID 27768 | — |
반응 단계
6-Bromo-2-naphthol (500 mg, 2.242 mmol, 1 eq) and NBS (558.7 mg, 3.319 mmol, 1.4 eq) are stirred at RT in 4.4 ml of acetone and 22 μl of 1 N HCl for 15 min. Ethyl acetate is added, and this organic phase is washed three times with 1 N HCl. After drying over magnesium sulfate, filtering and concentrating in vacuum on a rotary evaporator, the desired product is obtained in quantitative yield (677 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08546392B2 |
| 출처 데이터셋 | uspto-grants-2013_10 |
| ORD ID | ord-b68191a7d1f54bb5a505f482983b8aca |
| 출처 메모 | uspto-grants-2013_10 |