Toluene → HCID 178501285, 화합물

HRID 1035712노트

반응식

HRID 1035712 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][CH:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]1.[C:11]1(C)C=CC=CC=1.C[Si](C=[N+]=[N-])(C)C>CO>[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([O:10][CH3:11])=[O:9])[CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 1511384-Hydroxycyclohexanecarboxylic acidHCID 167693Trimethylsilyldiazomethane

생성물 1

HCID 178501285HCID 178501285, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1 g of 4-hydroxycyclohexanecarboxylic acid (6.94 mmol, 1 eq.) is placed in 50 mL of a 4/1 mixture of toluene and methanol. 5.55 mL of trimethylsilyldiazomethane (11.10 mmol, 1.6 eq.) are added dropwise to the reaction medium with stirring. After 16 hours, the solvents are evaporated off to give 1.3 g of methyl trans-4-hydroxycyclohexanecarboxylate.

후처리

  1. customthe solvents are evaporated off

출처 및 근거

ORD 기록
ord-109d657e1ccb4dd98a08c33cb5cef98c
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546391B2

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