홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → Oxetan-2-ylmethyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)carbamate

HRID 1035772
노트
인쇄 미리보기

반응식

HRID 1035772 반응식
[C:1]1([O:7][C:8](=[O:36])[NH:9][C:10]2[S:11][C:12]3[CH:18]=[C:17]([S:19][C:20]4[N:24]5[N:25]=[C:26]([C:29]6[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=6)[CH:27]=[CH:28][C:23]5=[N:22][N:21]=4)[CH:16]=[CH:15][C:13]=3[N:14]=2)C=C[CH:4]=[CH:3][CH:2]=1.[OH:37]CC1CCO1.C(N(CC)CC)C>O1CCCC1>[O:37]1[CH2:4][CH2:3][CH:2]1[CH2:1][O:7][C:8](=[O:36])[NH:9][C:10]1[S:11][C:12]2[CH:18]=[C:17]([S:19][C:20]3[N:24]4[N:25]=[C:26]([C:29]5[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=5)[CH:27]=[CH:28][C:23]4=[N:22][N:21]=3)[CH:16]=[CH:15][C:13]=2[N:14]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12284142(Oxetan-2-yl)methanolHCID 86707012Phenyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)carbamate

생성물 1

HCID 86707011Oxetan-2-ylmethyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)carbamate

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

반응 조건

온도
80 °C

실험 절차

a mixture of 171 mg of phenyl(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)carbamate, 0.04 cm3 of 2-hydroxymethyloxetane and 0.06 cm3 of triethylamine in 3 cm3 of tetrahydrofuran is heated for 7.5 h in a bath at 80° C. The reaction is left to stand overnight at 20° C. and then the mixture is evaporated to dryness under vacuum. The residue is purified by chromatography on a Merck cartridge of 25 g of silica 15-40 μm by solid deposit, elution being carried out with a dichloromethane/methanol gradient of 100/0 to 96/04. 52 mg of oxetan-2-ylmethyl(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)carbamate are thus obtained in the form of a white solid, the characteristics of which are as follows:

후처리

  1. waitThe reaction is left
  2. customthe mixture is evaporated to dryness under vacuum
  3. customThe residue is purified by chromatography on a Merck cartridge of 25 g of silica 15-40 μm by solid deposit, elution

출처 및 근거

ORD 기록
ord-22c81ee882c3416fb834a44e97c0602e
출처 데이터셋
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08546393B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트