Rac-(1r,4r)-4-methoxycyclohexane-1-carboxylic acid → (4-Methoxycyclohexyl)methanol

HRID 1035915

반응식

HRID 1035915 반응식
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH:6]([C:9](O)=[O:10])[CH2:5][CH2:4]1>O1CCCC1>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH:6]([CH2:9][OH:10])[CH2:5][CH2:4]1

참가 물질

3

반응물 1

HCID 736153Rac-(1r,4r)-4-methoxycyclohexane-1-carboxylic acid

생성물 1

HCID 18533153(4-Methoxycyclohexyl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4-Methoxycyclohexanecarboxylic acid (7 g) in tetrahydrofuran (20 mL) was treated with 1 M (in tetrahydrofuran) borane-tetrahydrofuran complex (100 mL) overnight. The mixture was concentrated and the residue was dissolved in methanol (100 mL) and concentrated HCl (10 mL). The resulting mixture was stirred for 1 hour and concentrated. The residue was dissolved in dichloromethane and washed with water. The organic layer was dried over Na2SO4, filtered, and concentrated to give the title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. dissolutionthe residue was dissolved in methanol (100 mL)
  3. concentrationconcentrated
  4. dissolutionThe residue was dissolved in dichloromethane
  5. washwashed with water
  6. dry with materialThe organic layer was dried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7e12cebf5b7c41e3bb4baf0e81312ea1
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546399B2

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