HCID 58447716, 화합물 → 6-(3-Fluorophenyl)pyridin-3-amine

HRID 1036295노트

반응식

HRID 1036295 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[H][H]>[Pd].CO>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 58447716HCID 58447716, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 463118956-(3-Fluorophenyl)pyridin-3-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a round-bottom flask was added 2-(3-fluorophenyl)-5-nitropyridine (3.8 g, 17 mmol), Pd/C (0.5 g) and methanol (100 mL). The reaction was stirred for 4 hours under hydrogen atmosphere by attaching a hydrogen balloon. The reaction was flushed with nitrogen and the solid was removed by filtration. The solvent was removed by rotary evaporation to give 6-(3-fluorophenyl)pyridin-3-amine 219-1 as brown solid. MS m/z 189.1 (M+1).

후처리

  1. customThe reaction was flushed with nitrogen
  2. customthe solid was removed by filtration
  3. customThe solvent was removed by rotary evaporation

출처 및 근거

ORD 기록
ord-8bf8494f00a847cea6272edcc214bdb2
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546396B2

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