Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → (R)-2-amino-2-(6-(4,4-dimethylcyclohexyloxy)naphthalen-2-yl)propan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | (R)-4-(6-(4,4-dimethylcyclohexyloxy)naphthalen-2-yl)-4-methyloxazolidin-2-one | HCID 67414756 | — |
| 생성물 | (R)-2-amino-2-(6-(4,4-dimethylcyclohexyloxy)naphthalen-2-yl)propan-1-ol | HCID 46196208 | — |
반응 단계
The mixture of (R)-4-(6-(4,4-dimethylcyclohexyloxy)naphthalen-2-yl)-4-methyloxazolidin-2-one and lithium hydroxide (45 mg, 0.0019 mol) in ethanol (1.1 mL, 0.019 mol) and water (0.37 mL, 0.021 mol) was heated to reflux for overnight. The crude product was partitioned between ethyl acetate and water and the ethyl acetate layer was concentrated and the crude was brought up in methanol and purified by HPLC. MS: m/z=311.2 [M−NH2]+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08546359B2 |
| 출처 데이터셋 | uspto-grants-2013_10 |
| ORD ID | ord-19785f35912243d49ad3902c1cce695b |
| 출처 메모 | uspto-grants-2013_10 |