HCID 71060655, 화합물 → 1-Oxo-4-pyridin-3-yl-2,7-diaza-spiro[4.5]decane-7-carboxylic acid tert-butyl ester

HRID 1036722노트

반응식

HRID 1036722 반응식
C([O:3][C:4]([C:6]1([CH:19]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)[CH2:20][NH2:21])[CH2:11][CH2:10][CH2:9][N:8]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:7]1)=O)C>C1(C)C=CC=CC=1>[C:15]([O:14][C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C:6]2([C:4](=[O:3])[NH:21][CH2:20][CH:19]2[C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)[CH2:7]1)=[O:13])([CH3:16])([CH3:17])[CH3:18]

참가 물질

3

반응물 1

HCID 71060655HCID 71060655, 화합물

생성물 1

HCID 710603511-Oxo-4-pyridin-3-yl-2,7-diaza-spiro[4.5]decane-7-carboxylic acid tert-butyl ester

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 3-(2-Amino-1-pyridin-3-yl-ethyl)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (2.5 g, 6.6 mmol) in toluene (21 ml) was heated at reflux overnight. The resulting mixture was concentrated in vacuo and the residue was purified by chromatography on silica eluting with 0-10% MeOH in DCM to afford the individual diastereomers as white solids:

후처리

  1. temperatureat reflux overnight
  2. concentrationThe resulting mixture was concentrated in vacuo
  3. customthe residue was purified by chromatography on silica eluting with 0-10% MeOH in DCM
  4. customto afford the individual diastereomers as white solids

출처 및 근거

ORD 기록
ord-9bb109a5bd184ddf9cd0ccd46232f26a
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546416B2

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