Benzoyl Peroxide → NCS Chloride

HRID 1036832

반응식

HRID 1036832 반응식
FC1C=CC=C(C)N=1.[CH2:9]1[C:14](=[O:15])[N:13]([Cl:16])[C:11](=[O:12])[CH2:10]1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C1C=CC=CC=1>[CH2:9]1[C:14](=[O:15])[N:13]([Cl:16])[C:11](=[O:12])[CH2:10]1.[Cl-:16]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 31398ChlorosuccinimideHCID 960902-Fluoro-6-methylpyridine

생성물 1

HCID 86612418NCS Chloride

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

2-Fluoro-6-methylpyridine (1.11 g, 10 mmol), NCS (2.0 g, 15 mmol), and catalytic benzoyl peroxide were dissolved in benzene and heated to reflux overnight. The reaction was concentrated and diluted with water and EtOAc. The organic layer was washed with saturated aq. NaHCO3, dried, filtered, and concentrated. The residue was purified on silica gel to give the desired product.

후처리

  1. temperatureheated
  2. temperatureto reflux overnight
  3. concentrationThe reaction was concentrated
  4. additiondiluted with water and EtOAc
  5. washThe organic layer was washed with saturated aq. NaHCO3
  6. customdried
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe residue was purified on silica gel

출처 및 근거

ORD 기록
ord-44f42961769046bcba442ac0cf87a814
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546431B2

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