Ethyl 4,5-dibromothiophene-2-carboxylate → Ethyl 4-bromo-5-(3-chlorophenyl)thiophene-2-carboxylate

HRID 1036987노트

반응식

HRID 1036987 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[S:5][C:6]=1[C:7]1[CH:12]=[C:11](F)[CH:10]=[C:9]([Cl:14])[CH:8]=1.BrC1C=C(C(OCC)=O)SC=1Br>>[Br:1][C:2]1[CH:3]=[C:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:14])[CH:8]=1

참가 물질

3

반응물 2

HCID 15073982Ethyl 4,5-dibromothiophene-2-carboxylateHCID 58066756Ethyl 4-bromo-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylate

생성물 1

HCID 58066739Ethyl 4-bromo-5-(3-chlorophenyl)thiophene-2-carboxylate

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 9A starting with the compound from Example 8A. 125 mg (57% of theory) of the title compound are obtained.

출처 및 근거

ORD 기록
ord-7f1c8a2e60684095a4b6c4cb14060a1f
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546438B2

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