Ethyl 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylate → 4-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylic acid

HRID 1036993노트

반응식

HRID 1036993 반응식
ClC1C=C(C2SC(C(O)=O)=CC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:34]=[C:35]([C:46]([O:48]CC)=[O:47])[S:36][C:37]=2[C:38]2[CH:43]=[C:42]([F:44])[CH:41]=[C:40]([Cl:45])[CH:39]=2)[CH:29]=[CH:30][C:31]=1[F:32]>>[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:34]=[C:35]([C:46]([OH:48])=[O:47])[S:36][C:37]=2[C:38]2[CH:43]=[C:42]([F:44])[CH:41]=[C:40]([Cl:45])[CH:39]=2)[CH:29]=[CH:30][C:31]=1[F:32]

참가 물질

3

반응물 2

HCID 58066743Ethyl 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylateHCID 580667575-(3-Chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

생성물 1

HCID 580667454-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylic acid

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 19A starting with the compound from Example 12A. The organic phase is concentrated and purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate/ethyl acetate:methanol 1:1 gradient) on silica gel. 0.43 g (100% of theory) of the title compound are obtained.

후처리

  1. concentrationThe organic phase is concentrated
  2. custompurified by flash chromatography (mobile phase: cyclohexane/ethyl acetate/ethyl acetate:methanol 1:1 gradient) on silica gel

출처 및 근거

ORD 기록
ord-5b488de93749427cbf16c75da2d35efd
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546438B2

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