Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylate → 5-(3-Chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylic acid

HRID 1036995노트

반응식

HRID 1036995 반응식
ClC1C=C(C2SC(C(O)=O)=CC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[S:37][C:36]([C:38]([O:40]CC)=[O:39])=[CH:35][C:34]=2[C:43]2[CH:48]=[CH:47][C:46]([F:49])=[C:45]([C:50]#[N:51])[CH:44]=2)[CH:29]=[C:30]([F:32])[CH:31]=1>>[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[S:37][C:36]([C:38]([OH:40])=[O:39])=[CH:35][C:34]=2[C:43]2[CH:48]=[CH:47][C:46]([F:49])=[C:45]([C:50]#[N:51])[CH:44]=2)[CH:29]=[C:30]([F:32])[CH:31]=1

참가 물질

3

반응물 2

HCID 58066742Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylateHCID 580667575-(3-Chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

생성물 1

HCID 580667555-(3-Chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylic acid

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 19A starting with the compound from Example 18A. 82.3 mg (97% of theory) of the title compound are obtained.

출처 및 근거

ORD 기록
ord-eb38378555a94d9abee1532849d9eca1
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546438B2

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