6-(2-azidopropan-2-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol → 6-(2-aminopropan-2-yl)-3,3-dimethylbenzo[c][1,2]-oxaborol-1(3H)-ol

HRID 1037052노트

반응식

HRID 1037052 반응식
[N:1]([C:4]([C:7]1[CH:8]=[CH:9][C:10]2[C:14]([CH3:16])([CH3:15])[O:13][B:12]([OH:17])[C:11]=2[CH:18]=1)([CH3:6])[CH3:5])=[N+]=[N-]>CO>[NH2:1][C:4]([C:7]1[CH:8]=[CH:9][C:10]2[C:14]([CH3:16])([CH3:15])[O:13][B:12]([OH:17])[C:11]=2[CH:18]=1)([CH3:6])[CH3:5]

참가 물질

3

반응물 1

HCID 866854956-(2-azidopropan-2-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

생성물 1

HCID 866854976-(2-aminopropan-2-yl)-3,3-dimethylbenzo[c][1,2]-oxaborol-1(3H)-ol수율 111.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The solution of 6-(2-azidopropan-2-yl)-3,3-dimethylbenzo[c][1,2]-oxaborol-1(3H)-ol (100 mg) in MeOH (6 mL) was hydrogenated under H2 using 10% Pd/C (15 mg) as catalyst at atmospheric pressure for 5 h. The catalyst was removed by filtration, and the solvent was evaporated at reduced pressure to give crude product 6-(2-aminopropan-2-yl)-3,3-dimethylbenzo[c][1,2]oxa-borol-1(3H)-ol (100 mg) as colorless oil. It was used without further purification in the next step.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated at reduced pressure

출처 및 근거

ORD 기록
ord-dfceee58e2474690adac0c3d68721a9c
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546357B2

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