3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-7-(2H-pyrazol-3-yl)-chromen-4-one

HRID 1037197

반응식

HRID 1037197 반응식
NC1(C2C=CC(C3C(=O)C4C(=CC=C(F)C=4)OC=3C3C=CC=CC=3)=CC=2)CCC1.C(OC(=O)[NH:36][C:37]1([C:41]2[CH:46]=[CH:45][C:44]([C:47]3[C:56](=[O:57])[C:55]4[C:50](=[CH:51][C:52]([C:58]5[NH:59][N:60]=[CH:61][CH:62]=5)=[CH:53][CH:54]=4)[O:49][C:48]=3[C:63]3[CH:68]=[CH:67][CH:66]=[CH:65][CH:64]=3)=[CH:43][CH:42]=2)[CH2:40][CH2:39][CH2:38]1)(C)(C)C>>[NH2:36][C:37]1([C:41]2[CH:42]=[CH:43][C:44]([C:47]3[C:56](=[O:57])[C:55]4[C:50](=[CH:51][C:52]([C:58]5[NH:59][N:60]=[CH:61][CH:62]=5)=[CH:53][CH:54]=4)[O:49][C:48]=3[C:63]3[CH:68]=[CH:67][CH:66]=[CH:65][CH:64]=3)=[CH:45][CH:46]=2)[CH2:40][CH2:39][CH2:38]1

참가 물질

3

반응물 2

HCID 510305983-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-oneHCID 67067641(1-{4-[4-oxo-2-phenyl-7-(2H-pyrazol-3-yl)-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

생성물 1

HCID 510307943-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-7-(2H-pyrazol-3-yl)-chromen-4-one수율 92%

실험 절차

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, (1-{-4-[4-oxo-2-phenyl-7-(2H-pyrazol-3-yl)-4H-chromen-3-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester was reacted to give the title compound as a cream solid (27 mg, 92%). 1H NMR (400 MHz, DMSO-d6): δ 13.36-13.12 (br s, 1H), 8.14-8.11 (m, 2H), 8.05-8.00 (m, 1H), 7.90-7.83 (br s, 1H), 7.48-7.33 (m, 7H), 7.21-7.17 (m, 2H), 7.00 (d, J=3 Hz, 1H), 2.47-2.39 (m, 2H), 2.24-2.15 (m, 2H), 2.08-1.97 (m, 1H), 1.73-1.64 (m, 1H). LCMS (Method F): RT=8.99 min, [M+H]+=434.

후처리

  1. customwas reacted

출처 및 근거

ORD 기록
ord-b13327ecf6854dac99f45e2c4085d23a
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546376B2

연결된 노트

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