5-Bromo-2-methoxybenzaldehyde → 1-(5-Bromo-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

반응식

F[C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1.COC1C=CC([Br:30])=CC=1C=O>>[Br:30][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1

참가 물질

반응물 2

HCID 906845-Bromo-2-methoxybenzaldehyde

HCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

생성물 1

HCID 670676311-(5-Bromo-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol수율 69%

실험 절차

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2-methoxy-5-bromobenzaldehyde was reacted to give the title compound as a colourless oil (440 mg, 69%). LCMS (Method B): RT=4.47 min, [M−OH+H]+=299/301.

후처리

customwas reacted

출처 및 근거

ORD 기록: ord-e0abc39257074cf0b7f5c0a649308d6c
출처 데이터셋: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08546376B2

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